{{ product.title }}

To: {{ product.giftCardToEmail }}
${{ getOriginalPrice(product) | formatPrice }}   ${{ product.totalDiscountAmount | formatPrice }} saved
${{ product.RRP | formatPrice }}
${{ product.totalPrice | formatPrice }}
Qty:{{ product.quantity }}
Your cart is empty.
Menu
Find a store

{{ product.title }}

To: {{ product.giftCardToEmail }}
${{ getOriginalPrice(product) | formatPrice }}   ${{ product.totalDiscountAmount | formatPrice }} saved
${{ product.RRP | formatPrice }}
${{ product.totalPrice | formatPrice }}
Qty:{{ product.quantity }}
Your cart is empty.

Combination Therapy Versus Intensification of Statin Monotherapy: an Update

Cardiovascular disease (CVD) includes conditions such as coronary heart disease, stroke, heart failure, arrhythmia, heart valve disease, congenital heart disease, and hypertension. The American Heart Association has estimated that CVD affects 83.6 million individuals in the U.S., contributes to 32.3% of deaths, and is a leading cause of disability. Atherosclerosis causes coronary heart disease (CHD), cerebrovascular disease, and peripheral artery disease. Abnormal lipoprotein metabolism predisposes individuals to atherosclerosis. Due to the consistent and robust association of higher LDL-c levels with atherosclerotic CVD across experimental and epidemiologic studies, therapeutic strategies to decrease risk have focused on LDL-c reduction as a primary goal. In contrast to LDL-c, high-density lipoprotein (HDL-c) has a protective role against atherosclerotic CVD. Questions remain as to how best to modify lipid levels with the goal of preventing CHD. The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are the most widely prescribed lipid-lowering agents and are often used as monotherapy. However, some patients do not reach their treatment goals on statin monotherapy or are troubled by side effects, prompting interest in combination therapy as a way to improve lipid levels without having to increase statin dosage or as a way to reduce side effects. Statins can be combined with an additional lipid-modifying medication such as a bile acid sequestrant, cholesterol absorption inhibitor, fibric acid, nicotinic acid, or omega-3 fatty acid. There are potential benefits to treating with multiple agents, as the different mechanisms of action of the other lipid-modifying agents may produce benefits unlikely to be achieved with a statin alone. For example, a fibrate or niacin in combination with a statin may increase HDL-c and decrease triglycerides above what is achieved with statin treatment alone. Combination therapy could potentially result in fewer statin-related side effects, as lower doses of statin could be used. Conversely, a combination of agents could result in an increase in side effects, as patients may experience the side effects common to both drugs. Two contextual factors need to be kept in mind while considering the evidence comparing statin intensification to combination therapy. First, guideline recommendations about intensifying statin therapy or adding an additional nonstatin agent to achieve a specific lipid target level have recently changed. Second, several large trials have compared statin monotherapy to combination therapy with the same statin dose plus another lipid-lowering drug. These trials have demonstrated that "add-on" combination therapy can lead to superior lipid outcomes but fails to reduce atherosclerosis or lead to decreased rates of cardiovascular death, MI, revascularization, or stroke. This evidence calls into question previous assumptions that lowering LDL-c or raising HDL-c are always reliable predictors of improved clinical outcomes, as well as increasing the importance of patient-centered clinical outcomes for evaluating the effectiveness of lipid-modifying therapies. We aimed to assess the effectiveness, safety, and tolerability of the combination of statin and other lipid-modifying medication compared to intensification of statin monotherapy. The specific Key Questions addressed are: 1) For patients who require intensive lipid-modifying therapy, what are the comparative long-term benefits and rates of serious adverse events of coadministration of different lipid-modifying agents (i.e., a statin plus another lipid-modifying agent) compared with higher dose statin monotherapy? 2) Do these regimens differ in reaching LDL targets (or other surrogate markers), short-term side effects, tolerability, and/or adherence? 3) Compared with higher dose statins and with one another, do combination regimens differ in benefits and harms within subgroups of patients?
RRP $89.99
or 4 payments of $22.50 with Learn more
Booklovers earn $4.45 in rewards when purchasing this title
Available
Dispatches in 14-21 days
Get estimated delivery dates


Please note that in-store and online pricing may differ

PRODUCT DETAILS

  • Title: Combination Therapy Versus Intensification of Statin Monotherapy: an Update
  • Author: U. S. Department Human Services, Agency for and Quality
  • Publisher: CreateSpace Independent Publishing Platform
  • ISBN: 9781497319042
  • Length: 0.9 inch
  • Width: 8.5 inch
  • Languages: English
  • Subtitle: Comparative Effectiveness Review Number 132
  • Format: PaperBack
  • Category: Medicine
  • Publication Date: 12/03/2014
  • Pages: 398
  • Height: 11.0 inch

RATINGS & REVIEW

SHIPPING AND RETURNS


Due to delays with some suppliers, some online deliveries are taking a little longer than usual. Please continue to track your delivery via the link provided.

 

Christmas Order Cut-off Dates

Due to increased demand during the Christmas period, there may be some delays in shipment and delivery due to high traffic. The table below is a guide to our Christmas order cut-off dates, however please check your “ESTIMATED DELIVERY DATE” on all items ordered prior to checkout to ensure you receive your order by 24th December.

 
  In Stock Titles

Next Day Delivery
To Order

Dispatches in 4-5 days
To Order

Dispatches in 5-7 days
To Order

Dispatches in 5-14 days
To Order

Dispatches in 14-21 days
  Shipping - Saver Delivery ORDER BY
7th December
ORDER BY
1st December
ORDER BY
25th November
ORDER BY
14th November
ORDER BY
7th November
  Shipping - Express Delivery ORDER BY
10th December
ORDER BY
3rd December
ORDER BY
30th November
ORDER BY
21st November
ORDER BY
14th November
 

Delivery options: Shipping to an Australian address

 

Service Price per order
Australia wide
Delivery time1
After dispatch
Saver Delivery (Tracked)
via Australia post

Items in order will be sent as soon as they arrive in the warehouse. Order may come in multiple shipments, however you will only be charged a flat fee.
$7.95 2-10 days after all items have arrived in the warehouse
 Express Delivery2  (Tracked)
via StarTrack Express3

Items in order will be sent via Express post as soon as they arrive in the warehouse. Order may come in multiple shipments, however you will only be charged a flat fee.
$14.95  1-2 days after each item has arrived in the warehouse
 

1 The expected delivery period after the order has been dispatched via your chosen delivery method.
2 Express is not available on all items.
3 Please note this service does not override the status timeframe "Dispatches in", and that the "Usually Dispatches In" timeframe still applies to all orders.

NB All our estimates are based on business days and assume that shipping and delivery don't occur on holidays and weekends.

 

When will my book be dispatched from your warehouse?

Once we receive your order we verify it, complete invoicing and prepare your item(s) before we dispatch them from our Sydney warehouse.

You will notice that each product page on the Web site includes an estimated delivery date range for Saver Delivery, as well as for Express Delivery if it is available for that product.

This Estimated Delivery date range is a combination of:

  • the time to dispatch your order from our warehouse, and
  • the time taken to ship your order to you.

In addition to the estimated delivery date range, on the product page you will find how long an item will take to be dispatched.

  Dispatch time
The time it takes to verify the order, complete invoicing, prepare your item(s) and dispatch.  
Explanation
The dispatch time will depend on the status of your item(s) at our warehouse.  
 
Immediate download

Immediate download

Digital downloads only

Dispatches next business day

Usually dispatches next business day+

In stock at our warehouse.

Dispatches in 4-5 business days

Usually dispatches in 4-5 business days+

Order placed with supplier, estimated arrival time to warehouse is 4-5 business days. 

Dispatches in 5-14 business days

Usually dispatches in 5-14 business days+

Order placed with supplier, estimated arrival time to warehouse is 5-14 business days.


+ All our estimates are based on business days and assume that shipping and delivery don't occur on holidays and weekends.

 

When will my order arrive?

The Estimate Delivery Date is when your order is expected to arrive at your chosen delivery location.

Once you have submitted your order you will receive confirmation and status update emails.

  • If you order multiple items and they are not all in stock, we will advise you of their anticipated arrival times.
  • For items not readily available, we'll provide ongoing estimated ship and delivery time frames.
  • Once your order has been dispatched from our Sydney warehouse you will receive an Order Shipped status email. This will contain your tracking information

All our estimates are based on business days and assume that shipping and delivery don't occur on holidays and weekends.

 

Tracking delivery

Saver Delivery: Australia post

Australia Post deliveries can be tracked on route with eParcel. You can track your delivery by going to AusPost tracking and entering your tracking number - your Order Shipped email will contain this information for each parcel.

  • Delivery with Standard Australia Post usually happens within 2-10 business days from time of dispatch. Please be aware that the delivery time frame may vary according to the area of delivery and due to various reasons, the delivery may take longer than the original estimated timeframe.
  • If you have not received your delivery following the estimated timeframe, we advise you to contact your local post office first, as the parcel may be there awaiting your collection.
  • If you have not received any information after contact with Australia Post, please contact us to confirm that the details for delivery logged with us are correct. We will then contact you with the appropriate action.

Express Delivery via StarTrack Express

You can track your delivery by going to StartTrack tracking using your consignment number. The consignment number is emailed to you along with the invoice at the time of shipment.

  • Please be aware that the delivery time frame may vary according to the area of delivery - the approximate delivery time is usually between 1-2 business days.
  • For enquiries regarding the delivery of your order, contact Star Track Customer Service on 13 23 45 - and quote the above consignment number.
  • If you have not received any information after contact with Star Track, please contact us to confirm that the address for delivery logged with us are correct. We will then contact you with the appropriate action.

International delivery

To track orders sent by DHL, go to DHL tracking

 

International orders

Deliveries to destinations outside Australia are made by DHL courier, and cannot be made to post office boxes. Charges for international delivery destinations are available below. For international deliveries we will hold your order until we can send you all your items at once.

Parcel Weight New Zealand Hong Kong US & Canada United Kingdom
Up to 1kg $30 $35 $40 $45
1.5kgs $35 $45 $50 $60
2kgs $40 $50 $60 $70
2.5kgs $45 $60 $70 $80
3kgs $50 $65 $75 $90
3.5kgs $55 $75 $85 $100
4kgs $60 $80 $95 $105
4.5kgs $65 $85 $100 $115
5kgs $70 $95 $110 $125

 

If your order weighs more than 1.0kg (2.2lb, roughly equivalent to 1 or 2 paperbacks), we'll let you know what your delivery charge will be, and seek your approval before sending your order.

Please note that some countries may charge the recipient duties on the 'import' of parcels from time-to-time. As these charges are the responsibility of the recipient, please check the customs service in your destination country to see if charges are applicable.

To track orders sent by DHL, go to DHL tracking

 

Delivery restrictions

Remote areas: Please note that there may be a surcharge if shipping international orders to a remote area. You can check if the delivery address is in a remote area at DHL Remote Area Services.

Reshipping: If your order is returned to us by the delivery company due to incorrect or insufficient delivery details, you will be charged the cost of reshipping the order. Please note that if the delivery address is incorrect and the order has been shipped, depending on the delivery option selected we may not be able to change the delivery address until the order has been returned.

 

Problems with your delivery

In the event that the courier company fails to deliver your order due to invalid address information, they will return the order back to Dymocks Online.

Dymocks Online will do their best to ensure the information you have input is accurate. We cannot guarantee that your order will arrive at its destination if you have not provided correct address details and as much information as possible to assist the couriers when delivering e.g. company name, level, suite etc.

If your order has not yet been shipped you will need to send Dymocks Online an email advising the error and requesting a change in details. If your order has a status of "packed" or "shipped" we will not be able to guarantee any change in shipping details.

Unfortunately, you will be liable for any costs incurred in return to sender parcels if the information you provided was inaccurate.